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Scientists find humans age dramatically in two bursts – at 44, then 60
(URL) https://www.theguardian.com/science/article/2024/aug/14/scientists-fi... (https://www.theguardian.com)
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|u/CanvasFanatic - 1 month
|
|I feel like it's always good to read the discussion of study
|limitations: >In addition, the mean observation span for participants
|was 626 days, which is insufficient for detailed inflection point
|analyses. Our cohort’s age range of 25–70 years lacks individuals who
|lie outside of this range. The molecular nonlinearity detected might be
|subject to inherent variations or oscillations, a factor to consider
|during interpretation. Our analysis has not delved into the nuances of
|the dynamical systems theory, which provides a robust mathematical
|framework for understanding observed behaviors. Delving into this theory
|in future endeavors may yield enhanced clarity and interpretation of the
|data. Moreover, it should be noted that, in our study, the
|observed nonlinear molecular changes occurred across individuals of
|varying ages rather than within the same individuals. This is attributed
|to the fact that, despite our longitudinal study, the follow-up period
|for our participants was relatively brief for following aging patterns
|(median, 1.7 years; Extended Data Fig. 1g). Such a timeframe is
|inadequate for detecting nonlinear molecular changes that unfold over
|decades throughout the human lifespan. Addressing this limitation in
|future research is essential.
|u/kimcheery - 1 month
|
|Can you please explain that like I’m a smart me?
|u/CanvasFanatic - 1 month
|
|* Study can't differentiate between inherent changes adaptation
|resulting from lifestyle changes * Study is small. Only 108
|individuals total. Only 8 between 25 and 40 * Study lasted a little
|less than two years. The observed changes are not within individuals
|but by comparing different individuals of different ages * Study
|tested only blood samples. Can't differentiate tissue specific
|changes * Previous studies using different instruments by same
|author had estimated changes at 34
|u/kimcheery - 1 month
|
|So it’s basically not helpful and conclusions are tenuous at best?
|I’m invested because of it’s true I’m about to fall apart
|u/CanvasFanatic - 1 month
|
|My takeaway is that the idea this study actually contributes
|evidence towards is that there are non-linear elements to aging.
|The specifics (like the exact ages) should probably be taken
|with a grain of salt for now.
|u/lobsterbash - 1 month
|
|Yeah, I think there's a pretty strong chance that this point
|you mentioned, alone, kills the specific age hypothesis:
|>Study can't differentiate between inherent changes adaptation
|resulting from lifestyle changes People can, and do,
|suddenly change their thinking and behaviors toward less
|healthful patterns for whatever reason. Loss of job, worsened
|health status, relationship issues, etc. can cause a person to
|accelerate their own wear & tear. Perhaps these turns are
|statistically more likely to occur at certain ages, which
|could incorrectly look like there is something biologically
|driving aging at those points.
|u/nameofplumb - 1 month
|
|I appreciate these words as I round my 43rd year and am still
|getting mistaken for 20’s and waiting for the other shoe to
|drop.
|u/Drownthem - 1 month
|
|Research very rarely aims to answer a huge question like that in
|one go. This study basically asks "Should we spend more money
|investigating the potential for nonlinear age-related changes in
|humans?" and answer "Quite possibly, yes".
|u/Professional_Cheek16 - 1 month
|
|I'm 42 I read the head line and figured I got two years left.
|u/Waitn4ehUsername - 1 month
|
|51. Last 4-5 years its like my body is just screaming ‘nice try
|buddy’ Im active, exercise regularly, dont smoke eat well but like
|you kids(teenagers going into university) both my wife and I have
|very busy jobs but both remarked a few days ago getting ready for
|bed of the litany of aches, pains, general appearance aging.
|IDK,,, every year i guess just gotta take it slower and try to
|appreciate your time on this rock.
|u/flyinthesoup - 1 month
|
|Hah, 43 here. I'm bracing myself now, I've been feeling so good and
|strong after starting a gym routine last year, now I'm wondering if
|everything's gonna go south through no fault of my own. Stupid
|meatbag body. EDIT: I'm loving all the comments with their own
|workout journeys, and thank you for all your kind words! I'm
|certainly not quitting, no matter what my telomeres/hormones/entropy
|says. Fuck being weak!
|u/Consistent-Roof-5039 - 1 month
|
|I've dealt with back pain for at least 20 years. I I got a
|yoga strap about 6 months ago and have been using it regularly
|and my back is doing great now. My daughter got so tired of
|hearing me say yoga strap that she said to me, "if you say
|yoga strap one more time..." 😭
|u/hypnocookie12 - 1 month
|
|I’ll have to look into yoga straps.
|u/flyinthesoup - 1 month
|
|Lmao I hate you, you just reminded me that I do have one age-
|related ache. I'm an avid PC gamer, and in the last 4-5 years
|I've noticed my right shoulder actually hurting if I play
|something that requires a lot of mouse movements. Last time I
|fired Diablo3 I ended up with my whole right arm hurting. THAT
|is definitely age related, cause I've been playing pc games
|since the early 90s and it never hurted me. I'm thinking of
|going to a physiotherapist and work on it before my arm falls
|off, I'm finally gold in LoL after playing for 12+ years and I'm
|NOT going back to silver!
|u/ImpressiveWonder4195 - 1 month
|
|I have similar pains in my forearm from years of keyboard and
|mouse. I went to the doc and it's a repetitive use injury.
|Have to maintain good posture, stretch, and strengthen the
|muscles. It takes awhile for the injury to build up, I think
|that's why we get away with it when we're younger. And it
|takes a long time to heal, too
|u/flyinthesoup - 1 month
|
|It certainly does! I've been working out on and off since I was
|in college, and Covid did a number on me cause I couldn't go to
|the gym, then I got lazy and didn't go back once they opened up
|again. I really turned into a human marshmallow. My wake up call
|last year was when I was going up some stairs, and by the 3rd
|floor my legs couldn't be lifted anymore, but I wasn't out of
|breath! I just had zero strength! Now, I don't mind being a bit
|fat, but fuck being a weakling. That month I went back to the
|gym and I've been lifting harder than I've ever done in my life.
|I want muscles!
|u/Pale_Solution_5338 - 1 month
|
|Humans that give up*
|u/chrisdh79 - 1 month
|
|From the article: The study, which tracked thousands of different
|molecules in people aged 25 to 75, detected two major waves of age-
|related changes at around ages 44 and again at 60. The findings could
|explain why spikes in certain health issues including musculoskeletal
|problems and cardiovascular disease occur at certain ages. “We’re not
|just changing gradually over time. There are some really dramatic
|changes,” said Prof Michael Snyder, a geneticist and director of the
|Center for Genomics and Personalized Medicine at Stanford University and
|senior author of the study. “It turns out the mid-40s is a time of
|dramatic change, as is the early 60s – and that’s true no matter what
|class of molecules you look at.” The
|[research](https://www.nature.com/articles/s43587-024-00692-2) tracked
|108 volunteers, who submitted blood and stool samples and skin, oral and
|nasal swabs every few months for between one and nearly seven years.
|Researchers assessed 135,000 different molecules (RNA, proteins and
|metabolites) and microbes (the bacteria, viruses and fungi living in the
|guts and on the skin of the participants).
|u/UnstableStrangeCharm - 1 month
|
|If this is true, it would be cool if we could figure out why this
|happens. It’s not like these changes occur for no reason; especially
|if they happen to every person regardless of diet, exercise, location,
|and more.
|u/Thin-Philosopher-146 - 1 month
|
|I think we've known for a while that telomere shortening is a huge
|part of the "biological clock" we all have.  What I get from this
|is that even if the telomere process is roughly linear, there may be
|things in our DNA which trigger different gene expression based on
|specific "checkpoints" during the shortening process.
|u/truongs - 1 month
|
|So the answer to fix old age death would be increase/rebuild the
|telomeres somehow. We would still have to fix our brain
|deteriorating, plaque build up in the brain etc I believe 
|u/DreamHiker - 1 month
|
|changing telomere length has resulted in the creation of cancer
|cells in the past, but that was a while ago, so there might be
|newer research in the meantime with different findings.
|u/Ntropie - 1 month
|
|Cancer cells replicate very quickly. In order for the cancer
|to not die it needs to lengthen its telomeres again. By
|providing telomerase, we allow cancers that would otherwise
|die off on their own, to spread further.
|u/OneSchott - 1 month
|
|Sounds like cancer could be the key to immortality.
|u/Cloud_Chamber - 1 month
|
|Deadpool moment
|u/Electrical-Fuel-Ass - 1 month
|
|Come again? This time in my ear.
|u/Defiant_Ad_7764 - 1 month
|
|> cancer could be the key to immortality. not for
|certain, but in some ways it could be. there is the canine
|transmissible venereal tumor cancer which has been passed
|on for like 10,000 years from host to host almost like a
|parasitic organism for example. the tumor it forms in the
|dog is not genetically the same as the host dog and traces
|back to the originator canine thousands of years ago. it
|steals mitochondria from host cells which helps it to
|survive.
|u/11711510111411009710 - 1 month
|
|Damn that original canine has no idea that it has passed
|on a tumor for 10,000 years
|u/U_wind_sprint - 1 month
|
|That said, the new canine host (of the 10,000 year old
|symbiote) enjoys the combined knowledge and memories
|of all past hosts.
|u/tuna_cowbell - 1 month
|
|I just heard about this fella yesterday!! And
|technically it is made out of dog material, so it counts
|as a single-celled dog!
|u/Pwnie - 1 month
|
|Stupid question, but are human cancer cells not made
|out of human material?
|u/milk4all - 1 month
|
|Typical existence
|u/Mohander - 1 month
|
|You need all the cancers. It worked for Mr Burns
|u/best_of_badgers - 1 month
|
|See: Henrietta Lacks
|u/Futureleak - 1 month
|
|You should read into HeLa cells
|u/Tall_poppee - 1 month
|
|> Sounds like cancer could be the key to immortality. If
|you're Henrietta Lacks it kinda was.
|u/12thunder - 1 month
|
|Ever heard of [immortal cell lines?](https://en.m.wikipedi
|a.org/wiki/Immortalised_cell_line) Now you have. They’re
|cancer cells that multiply ad infinitum. And you could
|argue that those people are still around, even though the
|most famous and common ones, HeLa cells, were taken
|without their consent. Imagine being turned immortal
|without your consent into infinite tiny pieces of your
|former self. Philosophically, it’s kinda fucked up.
|u/burf - 1 month
|
|Just millions of Deadpools running around all fugly and
|superhuman.
|u/exotic801 - 1 month
|
|Isn't the reason Deadpool is fugly(in movie) because of
|the expirements and not super cancer?
|u/eat-more-bookses - 1 month
|
|Henrietta Lacks, the immortal woman
|u/Careless-Plum3794 - 1 month
|
|Not as outlandish an idea as some would think, Henrietta
|Lacks' cancer cells are still being in research despite
|her death occurring over 70 years ago. 
|u/tradingten - 1 month
|
|I had a lengthy conversation with a physics professor about
|this and she is adamant lenghtning telemores is not the
|outcome that will work. Very interesting field this, wish I
|was more knowledgeable about the processes driving it
|u/SmallTawk - 1 month
|
|why don't they try to cure cancer then? Cure cancer, grow
|tolomeers, win-win, I don't see why we are not doing this now.
|u/Weak_Feed_8291 - 1 month
|
|Someone get this man a Nobel prize
|u/Kappadar - 1 month
|
|Just cure cancer and cure ageing, why isn't anybody doing
|this?
|u/Arkayjiya - 1 month
|
|Even without the joke, that sounds like a terrible idea.
|We're not at a stage of our society where we can handle
|immortality. This would be a living nightmare.
|u/BrainDumpJournalist - 1 month
|
|But maybe like some of us can get a little bit? as a
|treat?
|u/Freeman7-13 - 1 month
|
|"Science progresses one funeral at a time"
|u/manleybones - 1 month
|
|If you don't have kids it should be available.
|u/mattdean4130 - 1 month
|
|Imagine if billionaires never died. It would be
|billionaires and the homeless. Zero inbetween.
|u/QfromMars2 - 1 month
|
|More like the opposite. Especially in the west we have
|the problem, that older generations become to weak to
|work but might live up to 100 years or more. The Idea
|of not-aging never retireing people sounds like a
|solution to many problems of western societies,
|especially since many people don’t want to have
|children nowadays. Also genetically immortal people
|would also die by accident or sicknesses… so
|overpopulation might not be that big of a deal.
|u/SmallTawk - 1 month
|
|thanks, I'm not a scientist but I have good intuitions and
|I'm good at seing the big picture and using google. I
|should be the head manager of research, you know telling
|them what to work on. I could bring a climate of change.
|I'm thinking of repurposing a old mega mall and putting
|researchers in the stores so they can mingle at the food
|court and if they need to collaborate they can use little
|science themed electric carts to visit their peers and
|trade pipettes and usb sticks with research data.
|u/DreamHiker - 1 month
|
|every cancer is different, and killing the cells you wanted
|to keep growing for longer is sort of counter productive.
|u/radioactivegroupchat - 1 month
|
|It’d be like curing hunger in every country individually.
|Some hunger is caused by war, some by low crop yield, some
|by larger geopolitical influences, some by socioeconomic
|inequalities. For each reason there is a complex problem at
|hand and you have to solve it to get to the larger issue of
|hunger. Cancer is sort of like that.
|u/ButtNutly - 1 month
|
|We just need to make more sandwiches.
|u/cohortmuneral - 1 month
|
|> why don't they try to cure cancer then?
|https://imgur.com/a/NpRQ5pH
|u/eerae - 1 month
|
|Uh, we have been. Cancer is incredibly difficult to combat.
|I don’t think it will ever be “cured,” short of some kind of
|CRISPR tool that “fixes” all mutations.
|u/Bored_Amalgamation - 1 month
|
|Anybody who lives long enough will get cancer. It's a
|biological fact.
|u/jrppi - 1 month
|
|Apparently you can prevent plaque build up by sleeping enough.
|But hey, who has time for that. Not me!
|u/Practical_Cattle_933 - 1 month
|
|Not prevent, just decrease the rate. That’s very different.
|Just because proper care of your car can lengthen the time
|before some parts give up, it doesn’t mean it will run
|forever.
|u/eschewthefat - 1 month
|
|I’m following you 100%. The solution is a Toyota Hilux
|brain. Time to head back to the Middle East for some
|liberation 
|u/ThrownAway17Years - 1 month
|
|Every so often you drown it in sea water. And drop stuff
|on it. And then light it on fire. That brain will start
|right up. Not gonna be crisp, but it’s functional.
|u/cswella - 1 month
|
|That's what depressed people like me want to hear, sleeping 12
|hours a day will extend your life. ;)
|u/throwaway098764567 - 1 month
|
|i dunno man, when i'm really depressed i don't want life to
|last longer
|u/cswella - 1 month
|
|That's what I said.
|u/StevenAU - 1 month
|
|Being able to get a good nights sleep would be great, thanks
|Autism.
|u/iamjacksragingupvote - 1 month
|
|damn my brain prob got cavities
|u/bigbeatmanifesto- - 1 month
|
|And exercising!
|u/chantsnone - 1 month
|
|Mandatory naps everyday
|u/pine-cone-sundae - 1 month
|
|Some cultures embrace that. Some don't. Like mine :-(
|u/szymonsta - 1 month
|
|Kind of. Cancer cells are exceedingly good at rebuilding
|telomeres, so it might not be the way to go.
|u/truongs - 1 month
|
|Doesn't cancer rate increase because telomere is too short for
|cells to reproduce correctly?   Are you saying the cancer
|cell is able to repair its own mutant telomere so they can
|keep reproducing?   Maybe we find out how they can keep
|their mutant DNA intact while replicating forever 
|u/m_bleep_bloop - 1 month
|
|Yeah cancer cells turn off their own telomere based
|mortality as one of the key mutations to achieve
|unrestricted growth.
|u/theDinoSour - 1 month
|
|I think it’s the opposite. Telomeres can act as a genetic
|fuse. Cancer tends to lengthen then fuse, so apoptosis
|might not be happening correctly and you get unchecked cell
|growth, i.e. tumors.
|u/Evitabl3 - 1 month
|
|Telomeres as a rough measure of time+genetic damage is an
|interesting idea. Rather than actually having a causal
|effect on cell aging, it's just a pile of DNA that
|statistically gets damaged at a similar rate as the real
|mechanisms. As the telomeres get damaged, so too does the
|truly important stuff, and a shortened telomere indicates
|a higher likelihood of damage to other structures. It's a
|check engine/maintenance light, perhaps. When they get
|too short, it's time to euthanize to prevent cancer
|u/De3NA - 1 month
|
|That’s what they used in that lady’s cancer blood
|u/Sixwingswide - 1 month
|
|Do you mean Henrietta Lacks?
|https://www.hopkinsmedicine.org/henrietta-lacks
|u/TomerHorowitz - 1 month
|
|I'm genuinely curious, is there any research about it?
|u/truongs - 1 month
|
|For telemores yes. Scientists were able to extend them some.
|It increased the rate of cancer dramatically, so obviously
|something is missing in that. This was decades ago when I
|saw this. I wonder where it is now
|u/TomerHorowitz - 1 month
|
|That's fascinating, what did they do that caused cancer?
|u/blaaaaaaaam - 1 month
|
|One of the functions of telemeres is to prevent cancers.
|When a cancer cell goes haywire and starts replicating out
|of control, its telemeres will shorten until it destroys
|itself. Fiddling telemere length affects the body's own
|defenses against cancers.
|u/Nastypilot - 1 month
|
|IIRC, the process of rebuilding a telomere happens
|naturally in some cells, but upon reaching a certain stage
|of cell development that process stops and the cell begins
|to age. This is probanly done so that prolonged extension
|of the DNA doesn't lead to accumulation of mutations as
|the processes involved are the main places during which
|mutations take place. However a certain mutation, a part
|of a group of mutations that lead to expression of
|oncogenes, may reactivate said telomere extending process
|thus leading to potentially infinite cell reproduction,
|but also dramatically shooting up the rate at which a
|cell's DNA mutates which may lead to development of
|further expression of oncogenes and eventually cancer.
|u/CORN___BREAD - 1 month
|
|This is the focus of most of the anti-aging/life extension
|research I’ve read.
|u/DukeJukem152 - 1 month
|
|Another approach could be inhibiting the mechanism that checks
|telomere length and initiates these checkpoints, rather than
|altering telomeres directly. This could involve modulating
|checkpoint proteins, making epigenetic modifications, or
|targeting specific signaling pathways activated by telomere
|shortening.
|u/onda-oegat - 1 month
|
|Plaque maybe isn't the cause of Alzheimer's. Plaque cleansing
|drigs hasn't shown as good results as they hoped for.
|u/Ashamed-Status-9668 - 1 month
|
|It would be a much longer list. Would have to fix epigenetic
|changes too, for example.
|u/ArtBedHome - 1 month
|
|It would be a mistake to assume its a "deliberate action" like
|your body deciding you have lived too long: it is much MORE likely
|it is a result of "natural wear and tear", that all operating
|systems have. Eventually you run out of spare parts AND damage
|accrues on irreplaceable parts.
|u/cigarettesandwhiskey - 1 month
|
|Yeah I think the telomere thing is something people hope for
|because it'd be one magic bullet, but it's more likely just one
|thing in a thousand that produce the effects of aging. I think
|its more like you said - wear and tear, on every material and
|cell in every tissue in every organ, decade after decade. With
|not a lot of new parts or repair after the end of puberty.
|These thresholds in your 40s and 60s are probably just tipping
|points where - in general - some important systems reach a point
|where they no longer support other functions, and a cascade of
|interrelated things happen all at once. You'd need to fix all or
|most of them to avoid the threshold. Which is unfortunate,
|because if it was just one thing (like telomeres) it be a lot
|easier to develop a cure for old age.
|u/9212017 - 1 month
|
|Even with wear and tear the body can heal itself in some
|capacity, providing energy (calories) I wonder why can't the
|body just renew itself over and over.
|u/AcadiaFriendly - 1 month
|
|This is true. Which is why we’ve been studying for lobsters for
|years as they’re essentially immortal because of their unique
|telomeres
|u/MaxxDash - 1 month
|
|Imagine being immortal and then some Patriots fan snatches you
|out of the cold depths and kills you so you can end up at an
|all-you-can-eat buffet.
|u/WalrusTheWhite - 1 month
|
|Excuse me, we don't kill our lobster after snatching them out
|of the cold depths, that's disgusting. That's how you get food
|poisoning. We keep those little bastards alive until it's
|cooking time, like civilized folk.
|u/stonebraker_ultra - 1 month
|
|All-you-can-eat lobster? They have that?
|u/tonufan - 1 month
|
|The high end buffets do. You'd probably pay a ton in Vegas
|or like $30 in Vietnam.
|u/tastysharts - 1 month
|
|the universe is a funny thing
|u/kyrimasan - 1 month
|
|I find it very sad that lobsters are immortal but will die no
|matter what once they get too big to shed and then die a sad
|death squeezed and rotting to death.
|u/ChymChymX - 1 month
|
|And mortal because of Red Lobster
|u/MjrLeeStoned - 1 month
|
|Whatever it is seems to be on a 20 year cycle (maybe
|coincidentally, but still observable). Peak gene expression
|development ends around 20-25 years old. Next "spike" after
|another 20 years. Then another 20 years. Considering neanderthal
|had about a 35-40 year life span (mostly due to
|environmental/external factors), it could be tied into early
|hominid evolution where the original growth delineation to
|adulthood is a repeating cycle in gene expression, it just didn't
|factor in much until hominid life span started increasing.
|u/Stoli0000 - 1 month
|
|Not exactly right. While the average Neanderthal lifespan might
|be 45, a healthy individual who lives to 21 stood about as good
|a chance of making 80 as a hunter gatherer would today
|u/southwade - 1 month
|
|Yeah, infant mortality was pretty high. Skews the averages way
|down.
|u/Omniverse_0 - 1 month
|
|Now this is conjecture I can appreciate!
|u/ItsAllSoVeryTired - 1 month
|
|Telomere degradation is (most likely) a symptom of a greater
|cause. Take time to look up the epigenetic theory of aging, very
|ground breaking work.
|u/Realistic2483 - 1 month
|
|I don't feel like I quite have this right... Histones (?) bind to
|a DNA strand and block gene expression. This is how the same DNA
|can make several different types of cells doing different things.
|A researcher found that when the DNA strand breaks the histones
|(?) go to fix the DNA. Some of the histones (?) then go back to
|the wrong places. The wrong genes are blocked. This causes a
|cell to stop functioning correctly. Well a cell divides, the
|histones in both cells remember the positions. Thus, the two new
|cells have the same age. The researcher showed a mouse that he
|had aged rapidly by repeatedly breaking DNA and causing the
|histones to go back to the wrong places. The mouse had white
|hair, and was weak and lethargic. The researcher then reset the
|histones. The mouse's hair returned to its black or brown color,
|and was strong and energetic. Human or ape trials started a few
|months ago. I wish I could find that researcher and track their
|research.
|u/dicksjshsb - 1 month
|
|I’m also curious how they find such a defined range when people can
|have other age-triggered changes like puberty happen over a wide
|range. I always considered aging to be mostly drawn out changes
|over time due to build ups in the system, wear and tear on bones and
|muscles, etc that just happen over time due to physics. But it
|interesting to consider other changes triggered by the body’s
|internal clock.
|u/HomeschoolingDad - 1 month
|
|I did a quick CTRL-F enhanced look at the article, and I couldn't
|find any mention of what the standard deviation is, but I suspect
|it's several years, especially for the 60-year-old part of the
|data. My mother is in her 80s, and I feel like it's only been in
|the last 5 years that her health has started to decline more
|rapidly. Most of her hair is still black (really dark brown), and
|that's not due to dying it. My dad is also in his 80s, and his
|health hasn't yet seemed to have a significant decline.
|u/Objective_Guitar6974 - 1 month
|
|This right here. I've known people who were healthy all their
|lives and then when they hit 83 their bodies literally started
|falling apart. I've also seen for some it was the 60's.
|u/Garestinian - 1 month
|
|> The analysis revealed consistent nonlinear patterns in molecular
|markers of aging, with substantial dysregulation occurring at two
|major periods occurring at approximately 44 years and 60 years of
|chronological age.
|u/ScuffedBalata - 1 month
|
|That's an average, it's not some instant thing. They're looking
|at data and probably see a bell curve around 44 and 60. Much like
|the peak changes of puberty is a bell curve around 12-ish, but can
|range from like 8-15
|u/scrdest - 1 month
|
|Sorry, but this is... painfully off. Telomeres do not tell
|your body how to make anything - that's their whole point.
|Telomeres work for DNA like rubber washers do for screws or
|aglets for shoelaces. DNA always gets shorter when chromosomes
|get copied for... Reasons, whole separate post. Telomeres are
|noncoding, "junk" sequences of DNA that cap chromosomes, so that
|it's them that get lost and not the DNA bits behind them that
|carry *actual instructions*. Saying telomere shortening is the
|main cause of aging is wrong. It's a contributing factor at
|most. Even on a cellular level, mitochondrial disfunction and
|nuclear organisation getting messed up are the big boys (and in
|fact telomeres likely impact the latter).
|u/dicksjshsb - 1 month
|
|I didn’t know that, that’s interesting! Is that related to stem
|cells at all? The first thing I thought of reading your comment
|was hey why don’t we artificially recreate telomeres from a
|sample taken at a young age? But I’m sure someone’s tried that
|haha
|u/scrdest - 1 month
|
|You don't need too. Telomeres are a fixed DNA sequence, TTAGGG
|in humans. There is a protein (enzyme), telomerase reverse
|transcriptase or TERT, which is able to insert more of these
|guys.  We even have the genes to make it, but they are
|turned off in most cells in humans (unlike e.g. in mice IIRC).
|I believe that human stem cells do have it "on". The concern
|is TERT reactivation is used by SOME cancers to avoid
|committing die, so enabling it everywhere would make life
|easier for them - one less mutation needed.
|u/Soupdeloup - 1 month
|
|I'm genuinely curious if this is also true all around the world, or
|if it's just in one particular region. I have family in Korea and
|most of them look better in their 70s than my western family does in
|their 50s.
|u/Cinnamon_Bark - 1 month
|
|Could be lifestyle differences?
|u/Show_Me_Your_Rocket - 1 month
|
|Sugar is a helluva drug
|u/Krilox - 1 month
|
|Koreans are very good at using spf. Westerners often prefer to sun
|bathe. Sun exposure is like 80% of skin aging.
|u/Mean_Ratio9575 - 1 month
|
|Maybe something with telomeres dying off?
|u/AlphaCureBumHarder - 1 month
|
|Haven't read the article so I may be talking out of my ass here, but
|been in the medical field for a bunch of years, so here's my 2
|cents: biological aging doesn't really start until late 30s, so
|maybe the 44 average is the end of your most capable/younger body
|u/I_am_darkness - 1 month
|
|Yes as 43 year old it would be swell if we could figure it out RIGHT
|NOW
|u/avec_serif - 1 month
|
|So the study had 108 participants, but they ranged in age from 25 to
|75 and were tracked a median of only 1.7 years. How many actually
|crossed age 44 and 60 during the study? Squinting at their figures,
|it seems like at most 5 people were 44 during the study, and perhaps
|10 around age 60. On that basis alone I’m a bit skeptical of the
|conclusions.
|u/ramsan42 - 1 month
|
|Yeah what the hell kind of sample is that
|u/CONSOLE_LOAD_LETTER - 1 month
|
|The source article
|[here](https://www.nature.com/articles/s43587-024-00692-2)
|recognizes and makes mention of the limitations of the study and
|its small sample size and potential sample bias in the
|"Discussion" section of the paper. They mention this explicitly
|as something that should be addressed in subsequent research on
|the topic: > A further constraint is our cohort’s modest size,
|encompassing merely 108 individuals (eight individuals between 25
|years and 40 years of age), which hampers the full utilization of
|deep learning and may affect the robustness of the identification
|of nonlinear changing features in Fig. 1e. Although advanced
|computational techniques, including deep learning, are pivotal for
|probing nonlinear patterns, our sample size poses restrictions.
|Expanding the cohort size in subsequent research would be
|instrumental in harnessing the full potential of machine learning
|tools. Another limitation of our study is that the recruitment of
|participants was within the community around Stanford University,
|driven by rigorous sample collection procedures and the
|substantial expenses associated with setting up a longitudinal
|cohort. Although our participants exhibited a considerable degree
|of ethnic age and biological sex diversity (Fig. 1a and
|Supplementary Data), it is important to acknowledge that our
|cohort may not fully represent the diversity of the broader
|population. The selectivity of our cohort limits the
|generalizability of our findings. Future studies should aim to
|include a more diverse cohort to enhance the external validity and
|applicability of the results. The issue is that mainstream
|journalism always tends to paint the research in exaggerated,
|conclusive terms because that is what generates clicks, and
|mainstream people just read headlines and then jump to unfounded
|conclusions based on that.
|u/aTomzVins - 1 month
|
|> issue is that mainstream journalism I was probably about 35
|by the time I realized there's not even any point to reading
|mainstream stream science journalism. If a headline catches your
|attention the first thing you do is search for the link to the
|actual study and read their discussion and conclusion sections.
|I'm a sample of one, so don't think this happens to everyone at
|35. That's just about the age I gained access to more published
|science, and when I had time and interest in learning more about
|a particular topic.
|u/bigfathairymarmot - 1 month
|
|the answer is small, a small sample.
|u/Such_Credit_9841 - 1 month
|
|Surprised I had to scroll down so far to see someone point this out.
|I know it's very difficult to study a large number of people across
|a large timescale but this seems very flimsy to draw such
|conclusions.
|u/CaeruleanCaseus - 1 month
|
|Agree completely…very interesting study (and findings could be so
|useful) but way too small for me to put any real credit to this.
|It could also be that I’m 6- months from 44…so a little scared.
|u/Astronaut-Frost - 1 month
|
|I'd say this is most likely a worthless study. Because of the
|headline and being posted on reddit - thousands of people will
|start to believe in this decline
|u/DrSafariBoob - 1 month
|
|Agreed, this is terrible research to draw conclusions from.
|u/phpworm - 1 month
|
|I just turned 44 this year, so thank you for this I was a little
|worried
|u/hooplehead69 - 1 month
|
|Does that mean interventions timed specifically for these ages would
|be more effective at reducing the negative effects of aging overall?
|u/SartenSinAceite - 1 month
|
|At the very least, related health issues, which is already a great
|use of this finding
|u/DearLeader420 - 1 month
|
|Yeah the short term conclusion to this in my (non medical
|professional) mind is the same philosophy as "every man should
|have a prostate exam once they turn 30." Now you just have
|standard recommended checkups for other pathologies at 44 and 60.
|u/burf - 1 month
|
|I feel like medicine already roughly approximates these ages with
|their guidelines in some cases. Initial screening colonoscopies,
|prostate exams, EKGs, etc. are often targeted around the 40-50
|range.
|u/-iamai- - 1 month
|
|Just from observing friends 15 to 20 years older than myself there's
|definitely a "you've aged a lot" moments amongst them.
|u/skatecrimes - 1 month
|
|yeah early 40s.. ok just a number, "i feel 30".. but late 40s was
|like "im getting old" my blood test is showing some of the numbers
|going into the unhealthy range for no reason, same diet same
|exercise as when i was younger. Now i need to exercise a lot more to
|get those numbers right.
|u/EntrepreneurSmart824 - 1 month
|
|Usually related to some kind of major life change. I had a kid 2
|years ago in my 30s and it aged me 10 years…not sleeping does that.
|u/vincentxanthony - 1 month
|
|I’m curious as to if there are specifically similar bursts OVER 75 as
|well
|u/Gerryislandgirl - 1 month
|
|It said they think 78 is the spurt but they need to study it more. 
|u/two100meterman - 1 month
|
|I'm curious about this as well. I think it'd be somewhere in the
|80s, although it seems if you stay active enough that can be
|delayed? As an example the age 70-75 World record for the 100m dash
|for men is 12.59 seconds, that's within 3 seconds of Noah Lyles,
|they'd be around the 75m mark when a sub-10 sprinter hits the finish
|line. At 75-79 it increases to 13.25, 80-84 is 14.24, 85-90 is
|15.08, 90-94 is 16.69, 95-99 is 20.41, 100-104 is 26.99, 105-109 is
|34.50. It seems at 95 is a large time increase relative to the
|others. Although I assume sample size for people still being alive
|reduces drastically around this age as well.
|u/lewisae0 - 1 month
|
|Did it say men or women? Both?
|u/HollowBlades - 1 month
|
|Both. At first they assumed perimenopause and/or menopause had
|skewed their findings, but when they divided by sex, the changes
|were also seen in the men.
|u/liz_mf - 1 month
|
|both, according to the researchers' supplemental data. They do
|however note: "it is important to acknowledge that our cohort may
|not fully represent the diversity of the broader population. The
|selectivity of our cohort limits the generalizability of our
|findings."
|u/RainbowFuchs - 1 month
|
|Hmm, yeah, as someone who will have been on feminizing HRT for
|about 18 months when I turn 44 next year, I... hope that going
|through second puberty at the time will have a protective effect
|rather than intensify it! ^^*(Spironolactone ^^to ^^reduce
|^^blood ^^pressure, ^^dutasteride ^^to ^^prevent ^^male ^^pattern
|^^hair ^^loss, ^^progesterone ^^to ^^ensure ^^bone
|^^growth/density ^^from ^^the ^^estradiol, ^^et ^^cetera.)
|u/DevinCauley-Towns - 1 month
|
|52% of the participants are women and these 2 peaks were present at
|the same ages regardless of gender. If you look at figure 4 in the
|study, you can see there are many charts demonstrating these 2 peaks
|are fairly consistent across a variety of approaches. Gender is
|discussed within the paper, though not present in this figure.
|u/Jasfy - 1 month
|
|That’s an important element in guessing
|u/The_Sceptic_Lemur - 1 month
|
|Interesting. I recognized in myself I did quite an „aging“ jump last
|year. I thought it had to do with being quite stressed and anxious
|over some serious health issues of a close relative. But maybe it
|wasn‘t.
|u/ManicSelkieDreamGirl - 1 month
|
|108 seems like a reeeeeally small sample size
|u/danielbrian86 - 1 month
|
|108 people… not a scientist but this sounds like a small sample, no?
|u/ineedsomerealhelpfk - 1 month
|
|108 volunteers doesn't seem like a reliable sample size.
|u/HumptyDrumpy - 1 month
|
|Also depends if or when you have kids. World these days can be
|stressful asf to take care of oneself but that multiplies when you
|have others that depend on you so there is less leeway to mess up
|u/PrairiePopsicle - 1 month
|
|>"The research tracked 108 volunteers" Given the wide variations in
|total lifetime between genetic groups, specific towns, regions, and
|individuals, it's almost assuredly something along the lines of there
|being a variation in timing of these events between people that they
|could or did not quantify in the study. Perhaps you have some
|genetic variation which moved back your "aging event" into your 70's,
|and perhaps the timing of these events is related to overall longevity
|in these other cases where total lifetime was the focus.
|u/Mayankcfc_ - 1 month
|
|Why the comments are getting removed
|u/ScottyBoiBoi - 1 month
|
|Was wondering the same thing. Can only assume given that all of the
|accounts have been deleted too that they are all bots. Just a guess
|though
|u/realblurryface - 1 month
|
|It's like lotta people died here
|u/theCharacter_Zero - 1 month
|
|We are the leftovers?
|u/AshuriiiX - 1 month
|
|Reddit becoming north korea
|u/CeaseFireForever - 1 month
|
|Take care of yourself! Exercise, manage your diet and eat junk food in
|moderation, take your vitamins, have a proper skin care regime, learn to
|manage your stress when the going gets tough, don’t drive/take the bus
|everywhere and instead walk if you can, drink plenty of water and find
|hobbies that brings you joy. Aging will happen, but you can control it
|to an extent and age gracefully.
|u/Ameren - 1 month
|
|That and the whole point of research into the biology of aging is to
|find ways to slow it down and make it a more manageable condition.
|But no matter what the future holds, the first line of defense against
|aging is taking care of yourself, like you described. If diet and
|exercise were in pill form, it'd be the most effective and sought
|after drug ever.
|u/LEOVALMER_Round32 - 1 month
|
|THIS. Your comment should be way more above. I scrolled too far to
|find it.
|u/CarniferousDog - 1 month
|
|It says there’s a change in the process of caffeine and alcohol,
|what does that mean? I’m guessing it’s harder to process? Thanks.
|u/No_Distance6910 - 1 month
|
|Aging is inevitable, double bacon cheeseburgers are only enjoyed by
|the bold
|u/RyBread - 1 month
|
|I used to be bold. Now I b(e) old.
|u/TheWhooooBuddies - 1 month
|
|I don’t know about you all, but I’m gonna get my kicks in before
|this whole shithouse goes up in flames. Alright? YEAH!
|u/Yellowbug2001 - 1 month
|
|...if you're lucky, some people are just genetically ticking time
|bombs no matter how they live and it's pretty unfair, I've seen it in
|action. But you can stack the deck in your favor with healthy habits,
|and you can DEFINITELY reduce your odds of being lucky to 0 with
|unhealthy enough habits.
|u/wretch5150 - 1 month
|
|I'm not sure taking vitamins is even recommended anymore
|u/New_Forester4630 - 1 month
|
|> and eat junk food in moderation, Or just avoid it all together?
|u/mar21182 - 1 month
|
|It's tough. I've always been active. I love running and playing
|basketball. I like being fit. When I hit 40, I just started falling
|apart. Nagging injury after nagging injury that just never really
|recover. All the active things I liked to do, I have a hard time with.
|The will is there for staying in shape. My body is betraying me. My
|dad is 73 and still plays pick up basketball and softball. I always
|thought I'd be like him when I got older. Now, I don't know if I'll be
|able. I have cartilage loss in my knee and achilles tendonosis which
|is degenerative and doesn't really heal. I can't run 5ks any more
|because my knee will start to swell up when I try to start building up
|my weekly mileage. I play basketball, but it's a painful experience. I
|love the sport so much that I grit my teeth through it, but I don't
|know how much longer I can do that. I swear that aging gracefully is
|at least partially luck. You have to avoid injury. You have to have
|the right genetics. Your biomechanics have to be right as to not
|introduce excessive wear on your joints
|u/Heinrich-der-Vogler - 1 month
|
|Welcome to cycling, friend.
|u/jtenn22 - 1 month
|
|This study: - has only 108 participants - no pre existing conditions
|screened out - only residents of California is not representative of
|the US and geographic distribution could be flawed data wise - median
|follow up time is too short for this type of study -BMI was all over
|the place - there are so many variables with a small sample group it
|can’t possibly zero in on such specific numbers -different omics
|platforms introduce variability that can distort outcomes Not saying
|this study is wrong per se but shouldn’t be taken as gospel
|u/nanomolar - 1 month
|
|It's important to note, as the authors state when discussing the
|constraints of the study, that these 108 study participants were spread
|out over the ages of 25-70 and each individual was tracked for a mean
|time of 1.7 years, meaning that they were unable to observe these two
|inflection points within any one individual.
|u/lawroter - 1 month
|
|clinical researcher here and the headline/article are sensationalized
|garbage. is there anything of note in the findings? sure. but, to dumb
|it down to what is reported in either the title or headline is
|laughable. there are significant challenges to the results of the study,
|admittedly so by the authors: > Regrettably, we do not have such
|detailed behavioral data for the entire group, necessitating validation
|in upcoming research. Although initial BMI and insulin sensitivity
|measurements were available at cohort entry, subsequent metrics during
|the observation span were absent, marking a study limitation. a lack of
|this data at any point other than screening is suspect. > A further
|constraint is our cohort’s modest size, encompassing merely 108
|individuals (eight individuals between 25 years and 40 years of age),
|which hampers the full utilization of deep learning and may affect the
|robustness of the identification of nonlinear changing features in
|Fig. [1e](https://www.nature.com/articles/s43587-024-00692-2#Fig1).
|Although advanced computational techniques, including deep learning, are
|pivotal for probing nonlinear patterns, our sample size poses
|restrictions. an admittedly modest sample size, notably only 8
|individuals between 25-40 years, while noting a 'dramatic aging burst'
|at 44? questionable.
|u/IhvolSnow - 1 month
|
|The sample size is such a joke.
|u/thespaceageisnow - 1 month
|
|“The research tracked 108 volunteers“ fairly small sample size for
|results like this.
|u/StranzVanWaldenberg - 1 month
|
|you are correct. The right sample size depends on what you are
|researching. For more precise estimates, especially when accounting
|for various confounding factors (e.g., gender, lifestyle, health
|conditions), larger samples are needed.
|u/TWVer - 1 month
|
|Hmm.. I wonder if this is somehow related to the lifetime of cells
|within the human body, which is around [7 to 10
|years](https://www.sciencefocus.com/the-human-body/what-cells-in-the-
|human-body-live-the-longest), with the average cell age being around [16
|years](https://cordis.europa.eu/article/id/24286-life-span-of-human-
|cells-defined-most-cells-are-younger-than-the-individual) in general.
|Reading the article, the study rules out it being just (peri-)menopause
|related as the effects as seen just as strongly with men as well. I
|could see it having to do with times when the majority of the older
|generation of cells have died off, passing the torch to newer cells,
|which carry more DNA-defects (resulting in tissue damage) resultant from
|each cell division. The passing of cell generations might not be
|gradual, if a lot of cells (and their predecessors) originated around
|the same time (starting with first generation at conception). Perhaps
|that’s an hypothesis to study in the years ahead.
|u/TWVer - 1 month
|
|Preface: I’m no biologist nor an expert in any related field, so my
|answer isn’t worth a lot. ;) I believe there are studies looking at
|reducing the onset of cancer and other DNA-degeneration related
|diseases, which in certain cases focus on finding (almost) defective
|cells earlier. However, I could imagine it could perhaps become a
|self-defeating exercise as each cell needs to be replaced anyway.
|The culled sells still need to be replaced, even if they aren’t fit
|enough to do so. You could perhaps envision DNA-damage from
|occurring (or rather to delay it), by having regenerating telomeres.
|However, that will likely come with certain drawbacks if found to be
|technically possible at one point in time.
|u/Inside_Refuse_9012 - 1 month
|
|>You could perhaps envision DNA-damage from occurring (or rather
|to delay it), by having regenerating telomeres. However, that will
|likely come with certain drawbacks if found to be technically
|possible at one point in time. We have experimented with it.
|Turns out the shortening of our telomeres are one of our main
|defenses against cancer. Making cells require two unlikely
|mutations (telomere regeneration, and excessive replication) to
|become problematic. The drawback is cancer, and a lot of it. So
|while it is technically possible, it just means you die. Making it
|fairly worthless.
|u/Bring_Me_The_Night - 1 month
|
|Each cell type has a specific lifetime, it is not a good approach to
|consider the average lifespan of a cell while your body replaces cells
|in a different manner. Your skin cells may have a very short lifespan,
|due to exposure to environmental conditions. Your neurons will mostly
|outlive you. The kidneys cells don’t replicate at all. Fat cells live
|on average 9,7 years (and this does not seem to please people who want
|to lose weight). The molecular and cellular damage are tanked by the
|healthy tissue to maintain the body health and result in minimal
|physiological changes. You start to notice the aging of your body when
|it cannot hide the damage anymore. DNA damage and telomere erosion are
|primed as primary hallmarks of aging, but they rarely directly induce
|death in study models. Epigenetic dysregulations for instance (loss of
|tumor suppressor genes, increased activity of oncogenes, release of
|transposons) are much more harmful and are likely to induce much more
|signifiant damage. I may add that telomere erosion also acts as a
|barrier against tumorigenesis (it’s not all negative).
|u/EpitaphNoeeki - 1 month
|
|Thank you for taking the time to write a well thought out comment, I
|thought I was going insane in this thread
|u/stealthy_eater - 1 month
|
|Why is there so much removed here? Damn.
|u/phazyblue - 1 month
|
|What is going on with this thread? Why is it so heavily moderated??
|u/Didact67 - 1 month
|
|I’m not convinced it isn’t stress related at 44. Lot of people probably
|dealing with teenage kids at that age.
|u/newredheadit - 1 month
|
|And also taking care of aging parents
|u/Ms-Anthrop - 1 month
|
|Did they include women in this study? I ask because Menopausal women
|have been having our symptoms ignored or dismissed. Lack of estrogen
|around 50-53 seems to be aging many women in those age ranges pretty
|quickly in a few months time. It didn't happen for me at 44, but 51 and
|52.
|u/Drunkpanada - 1 month
|
|Yes "The mid-40s ageing spike was unexpected and initially assumed
|to be a result of perimenopausal changes in women skewing results for
|the whole group. But the data revealed similar shifts were happening
|in men in their mid-40s, too"
|u/ZweitenMal - 1 month
|
|I just turned 50 six weeks ago and the skin around my eyes has just
|collapsed since that time. I had really no wrinkles and now I am crepe
|city.
|u/FatherBax - 1 month
|
|Well if it helps. Crepes are delicious!
|u/The_I_in_IT - 1 month
|
|I was fine all throughout my 40’s, but 50 is hitting me like the old-
|fart truck.
|u/Kypsys - 1 month
|
|Please click on the link at the very least before asking question, the
|answer is right there in the article, you don't even need to read the
|whole study.
|u/dobermannbjj84 - 1 month
|
|I imagine the environment and things like diet could shift those ranges
|earlier or later as we see certain people who drink and smoke a lot tend
|to look mid 40’s in their 30’s and people with healthier lifestyles can
|look and appear 10-15 years younger.
|u/The_Singularious - 1 month
|
|Definitely. Genetics is a factor as well. I always looked younger than
|I am. In my 20s, it kinda sucked. But I’m grateful now. I’m no spring
|chicken, but I just got back from a class reunion and I’m doing just
|fine. My mom is in her mid 70s and could probably pass for 10 years
|younger. She also lives pretty clean and is very active.
|u/Vyracon - 1 month
|
|I guess it's different for everyone. I went through most of my 20s and
|30s without ever feeling old or aging. Then i had a kid at 36 and
|another at 39 and age hit me like a freight train before i was in my
|40s. Loss of hair, grey hair, presbyopia and gaining weight, constant
|pain random places, all the bad cliches. It's hell on wheels. Sleep
|deprivation, constant stress, unhealthy foods and no room for physical
|exercise all take their toll. (And please don't tell me that the last
|two parts are optional. Getting less than four hours of sleep per night
|for weeks and months does stuff to you. Your brain just goes into primal
|siege mode.) It's only been seven years, but i feel and look like i've
|aged decades.
|u/rs725 - 1 month
|
|Sounds like it was the child that did that to you and not necessarily
|a biological process.
|u/high5scubad1ve - 1 month
|
|Having a baby late 30s is not the same experience as having a baby
|at a younger age
|u/irulancorrino - 1 month
|
|If I keep reading articles like this I’m going to start looking like the
|cast of Love Island. This just makes me want to go get a ton of
|preemptive filler, start making extreme changes to slow my descent into
|decay.
|u/accordyceps - 1 month
|
|Premature aging is due to stress or illness or changes in lifestyle that
|affect health. This is pretty widely known.
|u/Decent_Night_5214 - 1 month
|
|Why are so many comments deleted????
|u/fredsherbert - 1 month
|
|wow that is so precise considering they are talking about 8 billion
|people who all have their own Extremely complex biology. but hey trust
|the experts
|u/saintkev40 - 1 month
|
|I think you can off set this by making big changes to your lifestyle.
|I'm 44 and I experienced this spike in aging , but I also started on
|wegovy and I am down 20 lbs in 2 months and should hit my target weight
|of 186 which is about what I weighed coming out of the army at 22.
|u/sevenproxies07 - 1 month
|
|Comment section looking like it hit age 60
|u/Nevermore5113 - 1 month
|
|What happened to all these comments? Damn.
|u/Absolutelynot2784 - 1 month
|
|What could people even say about this thats so controversial?
|u/pinkbowsandsarcasm - 1 month
|
|1) Have good genes?
|u/Hind_Deequestionmrk - 1 month
|
|Have good genes!
|u/lunagirlmagic - 1 month
|
|Another two points that kind of roll into one point: limit alcohol
|consumption and drink a ton of water. Alcohol is problematic all
|around but the biggest thing cosmetically is that it's a dehydrator
|and can wreck your skin if not paired with sufficient water
|consumption.
|u/100_points - 1 month
|
|This is the type of thing that's better to just not know about if true.
|I'm not passing on this info to any friends. Don't need that added
|subconscious stress at the back of the mind. I'll just doubly encourage
|everyone to take care of their bodies with better nutrition and
|exercise.
|u/JuggernautCheap - 1 month
|
|The sample size is 108 individuals. I'd like to know how varied they are
|over the global spectrum of diet, environment, socioeconomic status,
|race, etc., because that is a very small sample to come to these
|conclusions. My middle class parents are in their mid 70's. They seemed
|to age steadily up to this point. I had not seen my mother for several
|months after she turned 75 and when I saw her again I was shocked at how
|much she aged. My father, only over this last year has said he finally
|feels old. For what it's worth, my mother is a lifelong sober
|vegetarian and my father only eats meat 3 or 4 times a week tops. He has
|never been a heavy drinker and his only drunk stories are from his early
|20's. Once he got hitched, he would maybe have a few beers on weekends
|while watching football. Basically, take this study as a grain of salt.
|We need more data.
|u/Terror-Reaper - 1 month
|
|Puberty hits men and women at different ages for a number of years, but
|EVERYONE heavily ages at 2 specific years of their life, 44 and 60.
|u/haakongaarder - 1 month
|
|«Ability to metabolize alcohol» is mentioned as one of the age 45
|things. So it seems drinking less would help?
|u/Pineapplepizzaracoon - 1 month
|
|Pretty small sample size
|u/Bizzzle80 - 1 month
|
|Don’t have kids, don’t smoke, don’t drink, stay out of the sun,
|exercise, drink water. Easy
|u/creminibobini - 1 month
|
|Black don't crack, Brown don't frown, and Asian don't raisin. I have
|made my point. Take care of yalls bodies and you won't age like
|marshmallows in the sun.
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